Science, Tech, Math › Science Insoluble Definition (Chemistry) What Does Insoluble Mean? Share Flipboard Email Print Some substances may be insoluble in some cases; for example, water is insoluble in alcohol, but it is soluble in acid. Brian Edgar/Flickr/CC 2.0 SA Science Chemistry Chemical Laws Basics Molecules Periodic Table Projects & Experiments Scientific Method Biochemistry Physical Chemistry Medical Chemistry Chemistry In Everyday Life Famous Chemists Activities for Kids Abbreviations & Acronyms Biology Physics Geology Astronomy Weather & Climate By Anne Marie Helmenstine, Ph.D. Chemistry Expert Ph.D., Biomedical Sciences, University of Tennessee at Knoxville B.A., Physics and Mathematics, Hastings College Dr. Helmenstine holds a Ph.D. in biomedical sciences and is a science writer, educator, and consultant. She has taught science courses at the high school, college, and graduate levels. our editorial process Facebook Facebook Twitter Twitter Anne Marie Helmenstine, Ph.D. Updated February 07, 2019 Insoluble means incapable of dissolving in a solvent. It is rare for absolutely no solute to dissolve at all. However, many substances are poorly soluble. For example, very little silver chloride dissolves in water, so it is said to be insoluble in water. Note a compound may be insoluble in one solvent yet fully miscible in another. Also, several factors affect solubility. One of the most important is temperature. Increasing temperature frequently improves the solubility of a solute. Solutes Insoluble in Water Examples of compounds that are considered insoluble in water are the: Carbonates (except group I, ammonium, and uranyl compounds)Sulfites (except group I and ammonium compounds)Phosphates (except for some group 1 and ammonium compounds; lithium phosphate is soluble)Hydroxides (multiple exceptions)Oxides (multiple exceptions)Sulfides (except group I, group II, and ammonium compounds) Sources Clugston M. and Fleming R. (2000). Advanced Chemistry (1st ed.). Oxford: Oxford Publishing. p. 108.Hefter, G.T.; Tomkins, R.P.T (Editors) (2003). The Experimental Determination of Solubilities. Wiley-Blackwell. ISBN 978-0-471-49708-0.