'Grey's Anatomy' Relationships

Keep Track of the Relationships on Grey's Anatomy

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There are a lot of different relationships on Grey's Anatomy. Can you keep them all straight? Here's a rundown.


Derek Shepherd
Meredith sleeps with Derek before she realizes that he is her boss. In the beginning of season 1 she thwarts his advances but finally gives in. For a while they keep their relationship a secret, but it's not too long until the whole hospital knows. By the middle of season 1, they are no longer keeping it secret.

But at the end of season 1, Derek's wife shows up and the Derek/Meredith thing is over (for now).

In season 2, Meredith takes a guy home that she meets at Joe's. The next day, he needs to be seen at the hospital for his constant erection and Derek finds out that Meredith had slept with him. Meredith is embarrassed and Derek is hurt.

Finn Dandridge
Meredith begins dating the vet of her and Derek's shared dog, Doc. Derek realizes that he doesn't love Addison and doesn't want to be with her, but allows Meredith time to make her choice between him and Finn.

Meredith finally chooses Derek, but then he says he needs time to get over the fact that Addison had a relationship with Mark.

Derek Again
Meredith and Derek do end up back together, but then break up when Meredith can't commit. They continue having sex, until Derek starts dating a nurse, Rose. Meredith and Derek realize they belong together after working closely together and finally succeeding with a clinical trial.

Meredith reluctantly asks Derek to move in, which he does, but Meredith will not kick out her roommates, Izzie and Alex.

They decide to get married but give up their wedding so that Izzie and Alex can get married. They end up writing promises to each other on a Post-It Note and consider themselves married.


Preston Burke
Preston Burke notices Cristina and brings her coffee. She is surprised by this, but later when she walks in on him while he is changing, they hook up. Their relationship continues in secret throughout season 1. Cristina discovers she is pregnant but doesn't share this information and scheduled a D&C. In season 2, Cristina loses the baby and Burke finds out about the pregnancy. They get back together and Burke tells Chief Webber of their relationship.

Cristina has trouble coping with the fact that Burke may no longer be a great surgeon after he is shot. She comes up with a scheme so that Burke can operate without anyone knowing he has tremors in his hand. She is extremely upset when he asks her to step away from a surgery and tells the chief what is going on. Derek is able to fix Burke's hand.

He asks Cristina to marry him and she says yes, but he leaves her at the altar. Cristina is devastated and doesn't date again until Owen Hunt comes to Seattle Grace in season 5.

Owen Hunt
Owen was a major in the Army and is a trauma surgeon. He and Cristina begin dating, but break up after Owen chokes Cristina in his sleep, but as he goes through therapy, she gets back together with him.

They have a rocky relationship because Owen seems to be in love with both Cristina and Teddy Altman. He chooses Cristina, though.


Alex Karev

Izzie begins to show interest in Alex at the beginning of season 2. He takes her out on a date, but she has a horrible time. He doesn't even kiss her good night. She complains to George, and the next day Alex kisses her. Izzie thinks they have a relationship until she catches him in bed with George's ex-girlfriend, Olivia.

Izzie eventually forgives Alex and they continue dating until Izzie falls in love with Denny Dequette.

Denny Dequette
Denny is a patient of Burke's waiting for a new heart. Izzie cuts Denny's LVAD wire so that he will move up the donor list and get a heart. The surgery is successful, but Denny dies a couple of days later after proposing to Izzie.

Denny leaves Izzie 8.7 million dollars. Much to George's distress, she keeps the check under a magnet on the refrigerator, waiting until she thinks of something spectacular to do with it. When Bailey speaks of her idea to open a free clinic, Izzie invests her money into it.

Alex Again
A long time after Denny's death, Izzie begins dating Alex again, but she starts seeing Denny everywhere and even carries on a relationship with him, though she knows that he is dead. Once she realizes that it's cancer causing her to hallucinate, Izzie looks to Alex, and when she is at her sickest, they get married.

When she starts to get better, she distances herself from Alex and leaves for a while. She comes back and wants him back, but he says he deserves to be treated better than how she treats him. She leaves again.​


Izzie begins to show interest in Alex at the beginning of season 2. He takes her out on a date but seems distant. After hearing the complaints that he didn't even kiss her good night, he kisses her in Joe's bar. Alex has performance anxiety when he is with Izzie and ends up sleeping with Olivia, but Izzie catches him.

Izzie eventually forgives him and they begin dating again until Alex notices how close she is getting to a patient. After Denny's death, Alex carries Izzie away.

A while after Denny's death, they begin dating again. Alex feels her pulling away but won't break up with her.

When Izzie is really sick and it looks like she is going to die, Alex marries her. When Izzie starts to get better, the two find it hard to fall into a normal relationship and Izzie leaves.

Lexie Grey
Alex begins sleeping with Lexie and they soon begin a real relationship.


Meredith Grey
To begin with, everyone thought George was gay, but soon everyone but Meredith knew he was in love with her. George slept with Meredith when she was vulnerable despite knowing it was the wrong thing to do and he and Meredith had a strained relationship for quite some time after that.

Olivia Harper
George dates nurse Olivia Harper for a short time.

Callie Torres
Dr. Callie Torres begins to show interest in George, but they break up because George puts his friends ahead of Callie. They get back together and spontaneously get married in Vegas. One night, while drunk, George sleeps with Izzie. He and Callie break up and George tries to make things work with Izzie, but they have no sexual chemistry.


George O'Malley
Callie and George have an on again, off again relationship. Callie sleeps with Mark Sloan and feels terrible about it.

After helping George through a tough time with his dying father, George asks Callie to marry him and they run off to Vegas and get married. Callie is upset because George seems to always put his friends ahead of her. When he tells her that he slept with Izzie, she forgives him, but they soon break off their marriage.

Erica Hahn
Callie begins dating Erica Hahn, though she's terrified because she's never dated a girl before and doesn't know what to do. When they fight, Hahn leaves the hospital, leaving Callie behind.

Arizona Robbins
Callie begins dating Arizona Robbins and they are well matched and getting along great until Callie finds out that Arizona doesn't want to have children.

After the shoot out scare, Callie decides she can live without children, but she can't live without Arizona. Arizona says they can have dozens of kids.


Tucker Jones
Bailey is married to Tucker Jones for over 10 years, but they divorce because she puts too much of a priority on her job.

Ben Warren
Bailey reluctantly begins dating anesthesiologist Ben Warren. She gets upset when she sees him flirting with a nurse, but he says he's doing just to get in good with the nurses so they give him a better schedule. Bailey seems fine that with explanation.