Which Pathway Produces the Most ATP per Glucose Molecule?

ATP in Metabolic Pathways

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It's important to know how many ATP are produced per glucose molecule by various metabolic pathways, such as the Krebs cycle, fermentation, glycolysis, electron transport and chemiosmosis. Here is a look at how many net ATP are produced per pathway and which yields the most ATP per glucose.

Here is the breakdown of net ATP production:

  • Glycolysis: 2 ATP
  • Krebs Cycle: 2 ATP
  • Oxidative Phosphorylation (Electron Transport Chain/Chemiosmosis): 28 ATP

So, oxidative phosphorylation is the metabolic cycle that produces the most net ATP per glucose molecule.