Science, Tech, Math › Science Overview of the Thymus Gland It regulates the body's immune system Share Flipboard Email Print Science Biology Anatomy Basics Cell Biology Genetics Organisms Physiology Botany Ecology Chemistry Physics Geology Astronomy Weather & Climate By Regina Bailey Regina Bailey Biology Expert B.A., Biology, Emory University A.S., Nursing, Chattahoochee Technical College Regina Bailey is a board-certified registered nurse, science writer and educator. Her work has been featured in "Kaplan AP Biology" and "The Internet for Cellular and Molecular Biologists." Learn about our Editorial Process Updated on October 06, 2019 The thymus gland is the main organ of the lymphatic system. Located in the upper chest, this gland's primary function is to promote the development of cells of the immune system called T lymphocytes. T lymphocytes, or T-cells, are white blood cells that protect against foreign organisms (bacteria and viruses) that manage to infect body cells. They also protect the body from itself by controlling cancerous cells. From infancy to adolescence, the thymus is relatively large in size. After puberty, the thymus begins to shrink, which continues with age. Thymus Anatomy MedicalRF.com/Getty Images The thymus is a two-lobed structure in the upper chest cavity that partially extends into the neck. The thymus is above the pericardium of the heart, in front of the aorta, between the lungs, below the thyroid, and behind the breastbone. The thymus has a thin outer covering called a capsule and consists of three types of cells: epithelial cells, lymphocytes, and Kulchitsky, or neuroendocrine, cells. Epithelial cells: Tightly packed cells that give shape and structure to the thymus Lymphocytes: Immune cells that protect against infection and stimulate an immune response Kulchitsky cells: Hormone-releasing cells Each lobe of the thymus contains many smaller divisions called lobules. A lobule consists of an inner area called the medulla and an outer region called the cortex. The cortex contains immature T lymphocytes. These cells haven't developed the ability to distinguish cells of the body from foreign cells. The medulla contains the larger, mature T lymphocytes, which have the ability to identify self and have differentiated into specialized T lymphocytes. While T lymphocytes mature in the thymus, they originate from bone marrow stem cells. Immature T-cells migrate from the bone marrow to the thymus via the blood. The "T " in T lymphocyte stands for thymus-derived. Thymus Function The thymus functions chiefly to develop T lymphocytes. Once mature, these cells leave the thymus and are transported via blood vessels to the lymph nodes and spleen. T lymphocytes are responsible for cell-mediated immunity, an immune response that involves the activation of certain immune cells to fight infection. T-cells contain proteins called T-cell receptors that populate the T-cell membrane and are capable of recognizing various types of antigens (substances that provoke an immune response). T lymphocytes differentiate into three major classes in the thymus: Cytotoxic T cells: Directly terminate antigens Helper T cells: Precipitate the production of antibodies by B-cells and also produce substances that activate other T-cells Regulatory T cells: Also called suppressor T cells; suppress the response of B-cells and other T-cells to antigens The thymus produces hormone-like proteins that help T lymphocytes mature and differentiate. Some thymic hormones include thympoieitin, thymulin, thymosin, and thymic humoral factor (THF). Thympoieitin and thymulin induce differentiation in T lymphocytes and enhance T-cell function. Thymosin increases immune responses and stimulates certain pituitary gland hormones (growth hormone, luteinizing hormone, prolactin, gonadotropin-releasing hormone, and adrenocorticotropic hormone (ACTH)). Thymic humoral factor increases immune responses to viruses. Summary The thymus gland regulates the immune system through the development of immune cells responsible for cell-mediated immunity. In addition to immune function, the thymus also produces hormones that promote growth and maturation. Thymic hormones influence structures of the endocrine system, including the pituitary gland and adrenal glands, to assist in the growth and sexual development. The thymus and its hormones influence other organs and organ systems, including the kidneys, spleen, reproductive system, and central nervous system. Sources SEER Training Modules, Thymus. U. S. National Institutes of Health, National Cancer Institute. Accessed 26 June 2013 (http://training.seer.cancer.gov/) Thymus Cancer. American Cancer Society. Updated 11/16/12 (http://www.cancer.org/cancer/thymuscancer/detailedguide/thymus-cancer-what-is-thymus-cancer) Cite this Article Format mla apa chicago Your Citation Bailey, Regina. "Overview of the Thymus Gland." ThoughtCo, Sep. 7, 2021, thoughtco.com/thymus-anatomy-373250. Bailey, Regina. (2021, September 7). Overview of the Thymus Gland. Retrieved from https://www.thoughtco.com/thymus-anatomy-373250 Bailey, Regina. "Overview of the Thymus Gland." ThoughtCo. https://www.thoughtco.com/thymus-anatomy-373250 (accessed January 27, 2023). copy citation Watch Now: What Is the Circulatory System?